Selected Awards & Honors

Iwei Yeh, MD, PhD

Professor of Dermatology and Pathology

I graduated from Harvard College in 1997 with a degree in Biochemical Sciences. Then I returned to my native Bay Area to attend medical school at Stanford University. I finished my studies at Stanford in 2006 with an MD and a PhD in Biomedical Informatics. I completed my internship at Santa Clara Valley Medical Center in San Jose, CA and my dermatology residency at the University of Washington in Seattle, WA. During my residency I became interested in the genetics of melanocytic neoplasms and began a research path in the laboratory of Boris Bastian. I completed my dermatopathology fellowship at UCSF in 2011. After a brief stint at Memorial Sloan Kettering Cancer Center, I returned to UCSF as a faculty member.

I currently practice diagnostic dermatopathology as well as basic and pre-clinical research in the field of melanocytic neoplasia. There are many exciting new technologies that we can harness to improve diagnosis and treatment for our patients and understand the varied mechanisms that lead to skin cancer.

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Selected Publications

Theiler M, Oza VS, Mathes EF, Dvorak CC, McCalmont TH, Yeh I, Sidbury R, Cordoro KM. Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft-Versus-Host Disease. Pediatr Dermatol. 2017 Mar 20. doi: 10.1111/pde.13108. [Epub ahead of print] PubMed PMID: 28317161.

Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC. NTRK3 kinase fusions in Spitz tumours. J Pathol. 2016 Nov;240(3):282-290. doi: 10.1002/path.4775. PubMed PMID: 27477320; PubMed Central PMCID: PMC5071153.

Yeh I. Recent advances in molecular genetics of melanoma progression: implications for diagnosis and treatment. F1000Res. 2016 Jun 28;5. pii: F1000 Faculty Rev-1529. doi: 10.12688/f1000research.8247.1. eCollection 2016. Review. PubMed PMID: 27408703; PubMed Central PMCID: PMC4926755.

Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. The Genetic Evolution of Melanoma from Precursor Lesions. N Engl J Med. 2015 Nov 12;373(20):1926-36. doi: 10.1056/NEJMoa1502583. PubMed PMID: 26559571.

Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nat Genet. 2015 Oct;47(10):1194-9. doi: 10.1038/ng.3382. Epub 2015 Sep 7. PubMed PMID: 26343386; PubMed Central PMCID: PMC4589486.

Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. Activating MET kinase rearrangements in melanoma and Spitz tumours. Nat Commun. 2015 May 27;6:7174. doi: 10.1038/ncomms8174. PubMed PMID: 26013381; PubMed Central PMCID: PMC4446791.

Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC. Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions. Am J Surg Pathol. 2015 May;39(5):581-91. doi: 10.1097/PAS.0000000000000387. PubMed PMID: 25602801; PubMed Central PMCID: PMC4398593.

Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE. Ambiguous melanocytic tumors with loss of 3p21. Am J Surg Pathol. 2014 Aug;38(8):1088-95. doi: 10.1097/PAS.0000000000000209. PubMed PMID: 24705312; PubMed Central PMCID: PMC4101029.

Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013 Nov;26(6):845-51. doi: 10.1111/pcmr.12148. Epub 2013 Aug 19. PubMed PMID: 23890088; PubMed Central PMCID: PMC3808507.

Yeh I, von Deimling A, Bastian BC. Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia. J Natl Cancer Inst. 2013 Jun 19;105(12):917-9. doi: 10.1093/jnci/djt119. Epub 2013 May 20. PubMed PMID: 23690527; PubMed Central PMCID: PMC3687371.